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Impaired iron homeostasis is a central upstream determinant of ferroptosis sensitivity

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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In fact, it had been documented more than ten years earlier that when ascorbic acid and glutathione are together in the presence of the hexoxidase [ascorbate oxidase] described by Szent-Gyorgyi the glutathione wholly protects the vitamin from oxidation, whilst it is itself oxidized at a rate which, with the same concentration of enzyme, is exactly the same as the rate with which ascorbic acid is oxidized when alone. (Hopkins and Morgan 1938)